The nuclear pore complex: structure and function
نویسندگان
چکیده
منابع مشابه
The nuclear pore complex--structure and function at a glance.
Nuclear pore complexes (NPCs) are indispensable for cell function and are at the center of several human diseases. NPCs provide access to the nucleus and regulate the transport of proteins and RNA across the nuclear envelope. They are aqueous channels generated from a complex network of evolutionarily conserved proteins known as nucleporins. In this Cell Science at a Glance article and the acco...
متن کاملStructure and function of the nuclear pore complex.
Javier Fernandez-Martinez1,7, Seung Joong Kim2,7, Yi Shi3,7, Paula Upla4,7, Riccardo Pellarin2,6,7, Michael Gagnon5, Ilan E. Chemmama2, Junjie Wang3, Ilona Nudelman1, Wenzhu Zhang3, Rosemary Williams1, William J. Rice4, David L. Stokes4, Daniel Zenklusen5, Brian T. Chait3,*, Andrej Sali2,*, and Michael P. Rout1,* 1Laboratory of Cellular and Structural Biology, The Rockefeller University, New Yo...
متن کاملThe structure of the nuclear pore complex.
In eukaryotic cells, the spatial segregation of replication and transcription in the nucleus and translation in the cytoplasm imposes the requirement of transporting thousands of macromolecules between these two compartments. Nuclear pore complexes (NPCs) are the sole gateways that facilitate this macromolecular exchange across the nuclear envelope with the help of soluble transport receptors. ...
متن کاملA complex of nuclear pore proteins required for pore function
A family of proteins bearing novel N-acetylglucosamine residues has previously been found to be required to form functional nuclear pores. To begin to determine which of the proteins in this family are essential for pore function, antisera were raised to each of three members of the family, p62, p58, and p54. With these antisera, it was possible to deplete nuclear reconstitution extracts of the...
متن کاملThe nuclear pore complex
M OLECULAR trafficking between the nucleus and the cytoplasm of interphase eukaryotic cells occurs via the nuclear pore complexes (NPCs), 1 organelles with a roughly cylindrical shape (~,120 um in diameter and ~70-um high) that are embedded in the double-membraned nuclear envelope (NE). The NPC allows passive diffusion of ions and small molecules through an aqueous channel with a physical diame...
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ژورنال
عنوان ژورنال: Atlas of Genetics and Cytogenetics in Oncology and Haematology
سال: 2017
ISSN: 1768-3262
DOI: 10.4267/2042/62125